Browsing by Author "Ayodo, George"
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Adverse Neonatal Complications from Pregnancies Complicated by Gestational Diabetes Mellitus in a Poor Resource Setting, Kenya
Ottaro, Anita Amukhuma; Ayodo, George; Amolo, Asito Stephen (International Journal of Research in Engineering, Science and Management, 2024-01-01)Gestational diabetes Mellitus (GDM) is a disorder at pregnancy causing insulin intolerance thus contributing to adverse pregnancy outcomes. The aim of this study was to evaluate neonatal outcomes associated with gestational ... -
Ancient DNA Reveals a Multistep Spread of the First Herders into Sub-Saharan Africa
Prendergast, Mary E; Lipson, Mark; Sawchuk, Elizabeth A; Olalde, Iñigo; Ogola, Christine A; Rohland, Nadin; Sirak, Kendra A; Adamski, Nicole; Bernardos, Rebecca; Broomandkhoshbacht, Nasreen; Callan, Kimberly; Culleton, Brendan J; Eccles, Laurie; Harper, Thomas K; Lawson, Ann Marie; Mah, Matthew; Oppenheimer, Jonas; Stewardson, Kristin; Zalzala, Fatma; Ambrose, Stanley H; Ayodo, George; Gates, Henry Louis; Gidna, Agness O; Katongo, Maggie; Kwekason, Amandus; Mabulla, Audax ZP; Mudenda, George S; Ndiema, Emmanuel K; Nelson, Charles; Robertshaw, Peter; Kennett, Douglas J; Manthi, Fredrick K; Reich, David (American Association for the Advancement of Science, 2019-07-05)How food production first entered eastern Africa ~5000 years ago and the extent to which people moved with livestock is unclear. We present genome-wide data from 41 individuals associated with Later Stone Age, Pastoral ... -
Antibody Correlates of Protection from Clinical Plasmodium Falciparum Malaria in an Area of Low and Unstable Malaria Transmission
Hamre, Karen ES; Ondigo, Bartholomew N; Hodges, James S; Dutta, Sheetij; Theisen, Michael; Ayodo, George; John, Chandy C (The American Society of Tropical Medicine and Hygiene, 2020-12-02)Immune correlates of protection against clinical malaria are difficult to ascertain in low-transmission areas because of the limited number of malaria cases. We collected blood samples from 5,753 individuals in a Kenyan ... -
Antibody Profiles to P. falciparum Antigens over Time Characterize Acute and Long-Term Malaria Exposure in an Area of Low and Unstable Transmission
Ondigo, Bartholomew N; Hamre, Karen ES; Frosch, Anne EP; Ayodo, George; White, Michael T; John, Chandy C (The American Society of Tropical Medicine and Hygiene, 2020-12-02)Prevalence and levels of antibodies to multiple Plasmodium falciparum antigens show promise as tools for estimating malaria exposure. In a highland area of Kenya with unstable transmission, we assessed the presence and ... -
Antiretroviral (ARV) Drug Resistance and HIV-1 Subtypes among Injecting Drug Users in the Coastal Region of Kenya
Ng’ong’a, Gabriel O.; Ayodo, George; Kawaka, Fanuel; Knight, Veronicah; Ngayo, Musa; Lwembe, Raphael M. (Hindawi- Advances in Virology, 2022-02-10)HIV-1 genetic diversity results into the development of widespread drug-resistant mutations (DRMs) for the first-line retroviral therapy. Nevertheless, few studies have investigated the relationship between DRMs and HIV-1 ... -
Awareness of the Spectrum Condition of Autism among Pre-Primary School Teachers in Western Kenya
Sadia, Moses; Ayodo, George; Amimo, Fred; Itotia, Serah; Obinju, Christine; Ściborski, Romuald J. (African Journal of Health Sciences, 2023-06-13)Autism is a spectrum of neurodevelopmental disorders exhibited in early childhood with variable manifestations as children grow up. However, the level of awareness of the condition is poorly understood among pre-primary ... -
Barriers to Skilled Delivery among HIV Positive Women in Kakamega County of western Kenya
Juma, Erick Soita; Nyongesah, Maina John; Ayodo, George (East African Journal of Science and Technology, 2019)Childbirth at health facilities reduces maternal mortality, improves fetal outcomes and reduces mother-to-child transmission of HIV. Home delivery is associated with increased maternal and neonatal complications and death. ... -
Changes in b cell populations and Merozoite surface protein-1-specific memory b cell responses after prolonged absence of detectable p. falciparum infection
Ayieko, Cyrus; Maue, Alexander C.; Jura, Walter G. Z. O.; Noland, Gregory S.; Ayodo, George; Rochford, Rosemary; John, Chandy C. (PLOS, 2013-05)Clinical immunity to malaria declines in the absence of repeated parasite exposure. However, little is known about how B cell populations and antigen-specific memory B cells change in the absence of P. falciparum infection. ... -
Combining evidence of natural selection with association analysis increases power to detect malaria-resistance variants
Ayodo, George; Price, Alkes L.; Keinan, Alon; Ajwang, Arthur; Otieno, Michael F.; Orago, Alloys S. S.; Patterson, Nick; Reich, David (The American Society of Human Genetics, 2007-08)Statistical power to detect disease variants can be increased by weighting candidates by their evidence of natural selection. To demonstrate that this theoretical idea works in practice, we performed an association study ... -
Comorbidities Associated with Increased Risk of Death among Children Aged 2-59 Months with Severe Pneumonia in Western Kenya
Akoo, Timon Kwach; Awandu, Shehu Shagari; Oluoch, Felix; Kemunto, Lorine; Ochung, Antony; Ayodo, George (African Journal of Health Sciences, 2023-05-19)Globally, severe pneumonia remains the leading infectious cause of death in children younger than 5 years. Comorbidities increase the risk of death among children with severe pneumonia across age groups and regions; however, ... -
Computing the Geographic Extent of Maternity Health Services to Predict the Utilization of Skilled Delivery in Siaya County, Western Kenya
Oluoch, Felix; Ayodo, George; Owino, Fredrick; Okuta, Erick (European Scientific Journal- Research Gate, 2020-02)In Kenya, no study has attempted to incorporate the target population, nor the availability coverage and accessibility coverage to expose hidden gaps in the provision of maternity health services that target rural and ... -
The Cost Implications of Reaching Universal Coverage of Maternity Health Services in Siaya County, Western Kenya
Oluoch, Felix; Ayodo, George; Owino, Fredrick; Okuto, Erick (Public Health Research, 2020)In Kenya, no studies have attempted to model alternative scenarios of the cost-implications of reaching universal coverage (i.e. 95% population coverage) of the existing maternity health services network at the ward ... -
Decline in childhood iron deficiency after interruption of malaria transmission in highland Kenya1–3
Frosch, Anne EP; Ondigo, Bartholomew N; Ayodo, George; Vulule, John M; John, Chandy C.; Cusick, Sarah E (AJCN, 2014-07-30)Background: Achieving optimal iron status in children in malariaendemic areas may increase the risk of malaria. Malaria itself may contribute to iron deficiency, but the impact of an interruption in malaria transmission ... -
Decrease in numbers of naive and resting B cells in HIV-infected Kenyan adults leads to a proportional increase in total and Plasmodium falciparum–specific atypical memory B cells
Frosch, Anne E.; Odumade, Oludare A.; Taylor, Justin J.; Ireland, Kathleen; Ayodo, George; Ondigo, Bartholomew; Narum, David L.; Vulule, John; John, Chandy C. (The American Association of Immunologists, Inc., 2017-05-19)Human immunodeficiency virus type 1 (HIV-1) infection is associated with B cell activation and exhaustion, and hypergammaglobulinemia. How these changes influence B cell responses to coinfections such as malaria is poorly ... -
Decreased prevalence of anemia in highland areas of low malaria transmission after a 1-Year interruption of transmission
Noland, Gregory S.; Ayodo, George; Abuya, Jackson; Hodges, James S.; Rolfes, Melissa A. R.; John, Chandy C. (Oxford University Press, 2011-11-03)Background. Malaria control campaigns have reduced malaria transmission to very low levels in many areas of Africa. Yet the extent to which malaria interruption or elimination might decrease the prevalence of anemia in ... -
Determining the Prevalence and Density of Asymptomatic Plasmodium Falciparum Infections in Low and High Transmission Settings in Western Kenya
Salgado, Christina; Gaskin, Erik; Macklin, Michael; Onyango, Eliud; Surridge, Rachel; Nallandhighal, Srinivas; Bhardwaj, Jyoti; Datta, Dibyadyuti; Turnbull, Lindsey; O'Meara, Wendy; Ayodo, George; John, Chandy; Tran, Tuan (Creative Commons Attribution 4.0 International License, 2020-12-15) -
Diabetes Awareness and Risk Reduction Behaviors among Pre-Diabetic Patients in Busia County, Western Kenya
Munyasia, Linnet N.; Ayodo, George; Amimo, Fred; Wafula, Sam W. (International Journal of Development Research, 2021-01-30)One-third of people with pre-diabetic condition progress to type 2 diabetes within five years. However, with adequate knowledge on diabetes risk reduction behaviors, progression to diabetes can be controlled. We therefore ... -
An ethnic-specific polymorphism in the catalytic subunit of glutamate-cysteine ligase impairs the production of glutathione intermediates in vitro
Truc M.Le, Truc M.; Willis, Alecia S.; Barr, Frederick E.; Cunningham, Gary R.; Canter, Jeffrey A.; Owens, Sarah E.; Apple, Rachel K.; Ayodo, George; Reich, David; Summar, Marshall L. (ScienceDirect, 2010-09)Glutathione plays a crucial role in free radical scavenging, oxidative injury, and cellular homeostasis. Previously, we identified a non-synonymous polymorphism (P462S) in the gene encoding the catalytic subunit of ... -
Evaluating parental screening tool for developmental milestone in children under five years in rural Western Kenya
Ochieng, Christian B.; Ochanda, Damaris; Amimo, Fred A.; Njoki, Teresa Ita; Ikemeri, Justus E.; Ayodo, George (International Journal of Scientific and Research Publications, 2017-07)Background: An estimated 200 million children suffer from developmental delays, most in developing countries. Early diagnosis through screening is key to timely intervention. However, screening tools have not been assessed ... -
Evolution of the primate trypanolytic factor APOL1
Thomson, Russell; Genovese, Giulio; Canona, Chelsea; Kovacsics, Daniella; Higgins, Matthew K.; Carrington, Mark; Winkler, Cheryl A.; Kopph, Jeffrey; Rotimi, Charles; Adeyemo, Adebowale; Doumatey, Ayo; Ayodo, George; Alper, Seth L.; Pollak, Martin R.; Friedman, David J.; Rapera, Jayne (PNAS, 2014-04-08)ApolipoproteinL1 (APOL1) protects humans and some primates against several African trypanosomes. APOL1 genetic variants strongly associated with kidney disease in African Americans have additional trypanolytic activity ...