| dc.contributor.author | Menger, David J. | |
| dc.contributor.author | Omusula, Philemon | |
| dc.contributor.author | Holdinga, Maarten | |
| dc.contributor.author | Homan, Tobias | |
| dc.contributor.author | Carreira, Ana S. | |
| dc.contributor.author | Vandendaele, Patrice | |
| dc.contributor.author | Derycke, Jean-Luc | |
| dc.contributor.author | Mweresa, Collins K. | |
| dc.contributor.author | Mukabana, Wolfgang Richard | |
| dc.contributor.author | Van Loon, Joop J. A. | |
| dc.contributor.author | Takken, Willem | |
| dc.date.accessioned | 2022-02-22T07:22:44Z | |
| dc.date.available | 2022-02-22T07:22:44Z | |
| dc.date.issued | 2015-04-29 | |
| dc.identifier.citation | Menger DJ, Omusula P, Holdinga M, Homan T, Carreira AS, Vandendaele P, et al. (2015) Field Evaluation of a Push-Pull System to Reduce Malaria Transmission. PLoS ONE 10(4): e0123415. https://doi.org/10.1371/journal.pone.0123415 | en_US |
| dc.identifier.uri | http://ir.jooust.ac.ke:8080/xmlui/handle/123456789/10505 | |
| dc.description.abstract | Malaria continues to place a disease burden on millions of people throughout the tropics, especially in sub-Saharan Africa. Although efforts to control mosquito populations and reduce human-vector contact, such as long-lasting insecticidal nets and indoor residual spraying, have led to significant decreases in malaria incidence, further progress is now threatened by the widespread development of physiological and behavioural insecticide-resistance as well as changes in the composition of vector populations. A mosquito-directed push-pull system based on the simultaneous use of attractive and repellent volatiles offers a complementary tool to existing vector-control methods. In this study, the combination of a trap baited with a five-compound attractant and a strip of net-fabric impregnated with micro-encapsulated repellent and placed in the eaves of houses, was tested in a malaria-endemic village in western Kenya. Using the repellent delta-undecalactone, mosquito house entry was reduced by more than 50%, while the traps caught high numbers of outdoor flying mosquitoes. Model simulations predict that, assuming area-wide coverage, the addition of such a push-pull system to existing prevention efforts will result in up to 20-fold reductions in the entomological inoculation rate. Reductions of such magnitude are also predicted when mosquitoes exhibit a high resistance against insecticides. We conclude that a push-pull system based on non-toxic volatiles provides an important addition to existing strategies for malaria prevention. | en_US |
| dc.description.sponsorship | The laboratory work was funded by the European Union through NMP2-2009-228639, FP7, NOBUG project; the fieldwork was funded by a grant from the Foundation for the National Institutes of Health through the Grand Challenges in Global Health Initiative (GCGH#121). | en_US |
| dc.language.iso | en | en_US |
| dc.publisher | Plos One | en_US |
| dc.title | Field Evaluation of a Push-Pull System to Reduce Malaria Transmission | en_US |
| dc.type | Article | en_US |
