This quantitative study seeks to understand the impact of inventory management practices on the operational performance of public health facilities in Kisumu County, Kenya. The Objectives were to (1) determine the impact of the ABC system on the operation performance (cost management, waste management, and efficiency of service delivery) of public health facilities in Kisumu County; (2) examine the impact of the Economic Order Quantity system on the operation performance (cost management, waste management, and efficiency of service delivery) of public health facilities in Kisumu County; (3) investigate the impact of Just in Time on the operation performance (cost management, waste management, and efficiency of service delivery) of public health facilities in Kisumu County. Through stratified proportionate sampling, the study had a sample of 328 drawn from 1848 employees working in health facilities. From the findings, many respondents noted that the health facilities used the ABC system (84%), EOQ (96.4%), and JIT techniques (99.6%). The study found that the ABC system and operational performance of health facilities had correlation of (0.216); p < 0.000. Likewise, the EOQ technique and operational performance of health facilities had a correlation coefficient of (0.587); p < 0.001. JIT technique and operational performance of health facilities had a correlation of (0.439); p < 0.008. Lastly, the study established that the coefficients for the covariate (government policy) were not statistically significant (p>.05) indicating that government policy does not have a significant effect on the relationship between inventory management techniques and operational performance. This finding is not conclusive because the significance score was too high. Hence, the public health facilities in Kisumu County should continue improving their use of the techniques. Additional studies should be conducted.