Browsing School of Biological, Physical, Mathematics & Actuarial Sciences by Author "Mahanga, Geoffrey M."
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2-Hydroxy-4-Methoxybenzaldehyde: larvicidal structure-activity studies
Mahanga, Geoffrey M.; Akenga, Teresa O.; Lwande, Wilber; Ndiege, Isaiah O. (Chemical Society of Ethiopia, 2005)2-Hydroxy-4-methoxybenzaldehyde (1), a compound isolated from Mondia whytei (Hook) Skeels (Asclepiaceae) roots exhibited larvicidal activity (LD5022 mg/mL). A total of 18 other derivatives and closely related congeners ... -
Development, characterization and antimalarial efficacy of dihydroartemisinin loaded solid lipid nanoparticles
Omwoyo, Wesley N.; Melariri, Paula; Gathirwa, Jeremiah W.; Oloo, Florence; Mahanga, Geoffrey M.; Ogutu, Bernhards; Swai, Hulda (ELSEVIER, 2016-04)Effective use of dihydroartemisinin (DHA) is limited by poor water-solubility, poor pharmacokinetic profile and unsatisfactory clinical outcome especially in monotherapy. To reduce such limitations, we reformulated DHA ... -
The effect of varying the capping agent of magnetic/luminescent Fe3O4–InP/ZnSe core–shell nanocomposite
Paulsen, Zuraan; Onani, Martin O.; Allard, Garvin R.J.; Kiplagat, Ayabei; Okil, Joseph O.; Dejene, Francis B.; Mahanga, Geoffrey M. (ELSEVIER, 2016-01)Magnetic–luminescent nanoparticles have shown great promise in various biomedical applications namely: contrast agents for magnetic resonance imaging, multifunctional drug carrier system, magnetic separation of cells, cell ... -
Preparation, characterization, and optimization of primaquine-loaded solid lipid nanoparticles
Omwoyo, Wesley Nyaigoti; Ogutu, Bernhards; Oloo, Florence; Swai, Hulda; Kalombo, Lonji; Melariri, Paula; Mahanga, Geoffrey M.; Gathirwa, Jeremiah Waweru (PMC, 2014-08-11)Primaquine (PQ) is one of the most widely used antimalarial drugs and is the only available drug that combats the relapsing form of malaria. PQ use in higher doses is limited by severe tissue toxicity including hematological- ...