Browsing School of Health Sciences by Author "Reich, David"

Now showing items 1-3 of 3

    • Ancient DNA Reveals a Multistep Spread of the First Herders into Sub-Saharan Africa 

      Prendergast, Mary E; Lipson, Mark; Sawchuk, Elizabeth A; Olalde, Iñigo; Ogola, Christine A; Rohland, Nadin; Sirak, Kendra A; Adamski, Nicole; Bernardos, Rebecca; Broomandkhoshbacht, Nasreen; Callan, Kimberly; Culleton, Brendan J; Eccles, Laurie; Harper, Thomas K; Lawson, Ann Marie; Mah, Matthew; Oppenheimer, Jonas; Stewardson, Kristin; Zalzala, Fatma; Ambrose, Stanley H; Ayodo, George; Gates, Henry Louis; Gidna, Agness O; Katongo, Maggie; Kwekason, Amandus; Mabulla, Audax ZP; Mudenda, George S; Ndiema, Emmanuel K; Nelson, Charles; Robertshaw, Peter; Kennett, Douglas J; Manthi, Fredrick K; Reich, David (American Association for the Advancement of Science, 2019-07-05)
      How food production first entered eastern Africa ~5000 years ago and the extent to which people moved with livestock is unclear. We present genome-wide data from 41 individuals associated with Later Stone Age, Pastoral ...

    • Combining evidence of natural selection with association analysis increases power to detect malaria-resistance variants 

      Ayodo, George; Price, Alkes L.; Keinan, Alon; Ajwang, Arthur; Otieno, Michael F.; Orago, Alloys S. S.; Patterson, Nick; Reich, David (The American Society of Human Genetics, 2007-08)
      Statistical power to detect disease variants can be increased by weighting candidates by their evidence of natural selection. To demonstrate that this theoretical idea works in practice, we performed an association study ...

    • An ethnic-specific polymorphism in the catalytic subunit of glutamate-cysteine ligase impairs the production of glutathione intermediates in vitro 

      Truc M.Le, Truc M.; Willis, Alecia S.; Barr, Frederick E.; Cunningham, Gary R.; Canter, Jeffrey A.; Owens, Sarah E.; Apple, Rachel K.; Ayodo, George; Reich, David; Summar, Marshall L. (ScienceDirect, 2010-09)
      Glutathione plays a crucial role in free radical scavenging, oxidative injury, and cellular homeostasis. Previously, we identified a non-synonymous polymorphism (P462S) in the gene encoding the catalytic subunit of ...