Browsing School of Health Sciences by Subject "Malaria"
Now showing items 1-20 of 20
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Costs and cost-effectiveness of delivering intermittent preventive treatment through schools in Western Kenya
(BMC, 2008)Awareness of the potential impact of malaria among school-age children has stimulated investigation into malaria interventions that can be delivered through schools. However, little evidence is available on the costs and ... -
Decreased prevalence of anemia in highland areas of low malaria transmission after a 1-Year interruption of transmission
(Oxford University Press, 2011-11-03)Background. Malaria control campaigns have reduced malaria transmission to very low levels in many areas of Africa. Yet the extent to which malaria interruption or elimination might decrease the prevalence of anemia in ... -
Determinants of Malaria Prevalence among Children below Five Years in North West Kisumu Ward, Kisumu County, Kenya: A Cross-Sectional Study
(Middle East Journal of Applied Science & Technology, 2021-12-09)Globally, malaria remains a major public health problem. In 2019 an estimated 229 million cases of malaria were reported, WHO African region accounted for 94% of total cases. In Kenya, malaria is a leading cause of morbidity ... -
Determinants of the Uptake of Intermittent Preventive Treatment of Malaria in Pregnancy with Sulphadoxine Pyrimethamine in Sabatia Sub County, Western Kenya
(BMC, 2021)Annually, 125.2 million pregnant women worldwide risk contracting malaria, including 30.3 million and 1.5 million in Sub-Saharan Africa and Kenya respectively. At least three doses of sulphadoxine pyrimethamine for ... -
Effects of HIV-1 infection on malaria parasitemia in milo sub-location, western Kenya
(BMC, 2015)Malaria and HIV infections are both highly prevalent in sub-Saharan Africa, with HIV-infected patients being at higher risk of acquiring malaria. HIV-1 infection is known to impair the immune response and may increase the ... -
An ethnic-specific polymorphism in the catalytic subunit of glutamate-cysteine ligase impairs the production of glutathione intermediates in vitro
(ScienceDirect, 2010-09)Glutathione plays a crucial role in free radical scavenging, oxidative injury, and cellular homeostasis. Previously, we identified a non-synonymous polymorphism (P462S) in the gene encoding the catalytic subunit of ... -
Evaluation of three rapid diagnostic test kits in the diagnosis of plasmodium species infections among primary school children in Baringo County, Kenya
(scientific research, 2017)Background: Due to the difficulty in implementing microscopy-based definitive diagnosis of malaria especially in resource-poor areas, rapid diagnostic test (RDT) kits as alternatives have been developed by different ... -
Increased complement deposition on red blood cells in children with sickle cell trait
(BJMMR, 2015)Aims: Immune-mediated mechanism, such as deposition of complement (C3b) on erythrocytes leading to enhanced receptor-mediated uptake by macrophages has been proposed to contribute partly to the destruction of non-infected ... -
Lay knowledge and management of malaria in Baringo County, Kenya
(BMC, 2016)Background: Malaria, a disease caused by protozoan parasites of the genus Plasmodium and transmitted by female anopheline mosquitoes, is a major cause of morbidity, mortality and loss in productivity in humans. Baringo ... -
Malaria hotspot areas in a highland Kenya site are consistent in epidemic and non-epidemic years and are associated with ecological factors
(BMC, 2006)Background Malaria epidemics in highland areas of East Africa have caused considerable morbidity and mortality in the past two decades. Knowledge of "hotspot" areas of high malaria incidence would allow for focused ... -
Patterns and trends of malaria morbidity in Western highlands of Kenya
(International Journal of Education and Research, 2013-12)A study of patterns and trends of malaria morbidity was conducted in Kericho district in Kenya western highlands prone to occurrences of malaria epidemics. Kericho district supports small scale and large scale tea farming, ... -
Perennial transmission of malaria in the low altitude areas of Baringo County, Kenya
(BMC, 2017)Background: Malaria causes the greatest public health burden in sub-Saharan Africa where high mortality occurs mainly in children under 5 years of age. Traditionally, malaria has been reported mainly in the lowlands endemic ... -
Perennial transmission of malaria in the low altitude areas of Baringo County, Kenya
(BMC, 2017)Background Malaria causes the greatest public health burden in sub-Saharan Africa where high mortality occurs mainly in children under 5 years of age. Traditionally, malaria has been reported mainly in the lowlands endemic ... -
The Plasmodium falciparum antigen MB2 induces interferon-γ and interleukin-10 responses in adults in malaria endemic areas of Western Kenya
(PMC, 2013)Background: MB2 is a novel Plasmodium falciparum antigen of unknown function expressed in pre-erythrocytic and blood stages of infection in the human host. Interferon-gamma (IFN-γ) and interleukin (IL)-10 responses to ... -
Prevention of anaemia in pregnancy using insecticide-treated bednets and sulfadoxine-pyrimethamine in a highly malarious area of Kenya: a randomized controlled trial
(Elsevier, 2003-05)To compare the effects of intermittent treatment with sulfadoxine-pyrimethamine (SP) given during the second and third trimester of pregnancy, the use of insecticide-treated nets (ITN), or the combination of both on ... -
Red blood cell immune complex binding capacity in children with sickle cell trait (HBAS) living in p. falciparum malaria holoendemic region of Western Kenya
(IJTDH, 2012)Malaria infection leads to the formation of circulating immune complexes (CICs) which have been implicated in the pathogenesis of complicated malaria which includes severe malarial anemia. Children with sickle cell trait ... -
Relationships between anaemia and parasitic infections in Kenyan schoolchildren: A Bayesian hierarchical modelling approach
(Elsevier, 2008)Anaemia is multi-factorial in origin and disentangling its aetiology remains problematic, with surprisingly few studies investigating the relative contribution of different parasitic infections to anaemia amongst schoolchildren. ... -
Spatial clustering of malaria and associated risk factors during an epidemic in a highland area of western Kenya
(Blackwell publishing Ltd., 2004-07)The epidemiology of malaria over small areas remains poorly understood, and this is particularly true for malaria during epidemics in highland areas of Africa, where transmission intensity is low and characterized by acute ... -
Spatiotemporal Distribution of Rift Valley Fever and Malaria Vectors in Baringo County, Kenya: Implications on Vector Control
(International Journal of Mosquito Research, 2021-12-17)Rift Valley Fever and malaria are zoonotic and human diseases respectively that pose major production and health challenges to pastoralists. This study aimed to determine the spatiotemporal distribution of mosquito vectors ... -
Standardization and validation of a cytometric bead assay to assess antibodies to multiple Plasmodium falciparum recombinant antigens
(BioMed Central Ltd, 2012-12-21)Background Multiplex cytometric bead assay (CBA) have a number of advantages over ELISA for antibody testing, but little information is available on standardization and validation of antibody CBA to multiple Plasmodium ...