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Red blood cell immune complex binding capacity in children with sickle cell trait (HBAS) living in p. falciparum malaria holoendemic region of Western Kenya
(IJTDH, 2012)
Malaria infection leads to the formation of circulating immune complexes (CICs) which have been implicated in the pathogenesis of complicated malaria which includes severe malarial anemia. Children with sickle cell trait ...
Sickle cell trait (HbAS) is associated with increased expression of erythrocyte complement regulatory proteins CR1 and CD55 levels in children
(International Journal of TROPICAL DISEASE & Health, 2013)
Aims: Erythrocyte complement regulatory proteins, complement receptor 1 (CR1) and decay accelerating factor (CD55) protect red blood cells (RBCs) from complement mediated damage by controlling complement activation cascade ...
Increased complement deposition on red blood cells in children with sickle cell trait
(BJMMR, 2015)
Aims: Immune-mediated mechanism, such as deposition of complement (C3b) on erythrocytes leading to enhanced receptor-mediated uptake by macrophages has been proposed to contribute
partly to the destruction of non-infected ...