The objective of this study was to determine the influence of circulation space configuration attributes on the location of economic enterprises in Obunga informal settlement, Kisumu city. The study was based on street network modelling and analysis guided by the Space Syntax Theory. Spearman correlation coefficients of circulation space configuration attributes (betweenness, integration, connectivity and mean depth) were determined against the location of economic enterprises. The corresponding hypothesis was tested using a multilinear ANOVA regression model. Findings indicated a statistically significant relationship between circulation space configuration attributes with retail shops, food kiosk, M-pesas, and Barbershops and salons. Results of R-square values indicated that circulation space configuration attributes could predict the location of retail shops, food kiosks, M-pesas and barbershops and salons by 41%, 59.7%, 33.3%, and 33.4% respectively. Betweenness was found to be the best predictor of the location of economic enterprises in Obunga. The study concluded that economic enterprises are attracted along streets that can accommodate through movement in a settlement, thus, there is need to create and enhance quality of roads linking Obunga to its neighbors.