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Gametocytemia and Attractiveness of Plasmodium falciparum–Infected Kenyan Children to Anopheles gambiae Mosquitoes

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Publication Date
2017-06-13
Author
Busula, Annette O.
Mweresa, Collins K.
Masiga, Daniel
Logan, James G.
Sauerwein, Robert W.
Verhulst, Niels O.
Takken, Willem
De Boe, Jetske G.
Type
Technical Report
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Abstract/Overview

It has been suggested that Plasmodia manipulate their vertebrate hosts to enhance parasite transmission. Using a dual-choice olfactometer, we investigated the attraction of Anopheles gambiae to 50 Kenyan children (aged 5–12 years) who were naturally infected with Plasmodium falciparum or non-infected controls. Microscopic gametocyte carriers attracted almost 2 times more mosquitoes than children who were parasite free, harboured asexual stages, or had gametocytes at submicroscopic densities. By using highly sensitive stage-specific molecular methods to detect P. falciparum, we show that gametocytes and not their non-infectious asexual progenitors—induce increased attractiveness of humans to mosquitoes. Our findings therefore support the parasite host manipulation hypothesis.

Subject/Keywords
Chemical ecology; Olfactory behavior; Malaria transmission; Vector control; Host finding
Publisher
The Journal of Infectious Diseases
Permalink
http://ir.jooust.ac.ke:8080/xmlui/handle/123456789/9357
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