The study investigated the relationship between social support, resilience and drug abuse. A correlation research design was used, and adolescents between the age group of 14-23 years in four secondary schools in Koboko Town Council were randomly selected using a simple random sampling technique and 50 respondents were selected from each school bringing the total to 200 respondents. A three set structured questionnaire which measured adolescent resilience, social support and drug abuse was used to find out the relationship between the variables. The study findings showed a significant positive relationship between social support and resilience r = -.157; p = .029. Since the p value (.029) is smaller than the level of significance (.05), the hypothesis was retained; and found no relationship between social support and drug abuse r = .045; p = .303. Since the p value (.303) is greater than the level of significance (.05), the hypothesis was rejected; and no relationship between resilience and drug abuse r = .068; p = .223. Since the p value (.223) is greater than the level of significance (.05), the hypothesis was rejected. These findings led into conclusions that other factors apart from social support and resilience are believed to play a major role in adolescent drug abuse. It was therefore recommended that issues of adolescent development can and should be considered when designing and implementing preventive drug education programs.