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Interferon-γ responses to Plasmodium falciparum vaccine candidate antigens decrease in the absence of malaria transmission

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Publication Date
2017-01-10
Author
Ayieko, Cyrus
Ogola, Bilha S.
Ochola, Lyticia
Ngwena, Gideon A.M.
Ayodo, George
Hodges, James S.
Noland, Gregory S.
John, Chandy C.
Type
Article
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Citation

Ayieko C, Ogola BS, Ochola L, Ngwena GAM, Ayodo G, Hodges JS, Noland GS, John CC. 2017. Interferon-γ responses to Plasmodium falciparum vaccine candidate antigens decrease in the absence of malaria transmission. PeerJ 5:e2855

Abstract/Overview

Background Malaria elimination campaigns are planned or active in many countries. The effects of malaria elimination on immune responses such as antigen-specific IFN- γ responses are not well characterized. Methods IFN- γ responses to the P. falciparum antigens circumsporozoite protein, liver stage antigen-1, thrombospondin-related adhesive protein, apical membrane antigen-1, MB2, and merozoite surface protein-1 were tested by ELISA in 243 individuals in highland Kenya in April 2008, October 2008, and April 2009, after a one-year period of interrupted malaria transmission from April 2007 to March 2008. Results While one individual (0.4%) tested positive for P. falciparum by PCR inOctober 2008 and another two (0.9%) tested positive in April 2009, no clinical malaria cases were detected during weekly visits. Levels of IFN-γ to all antigens decreased significantly from April 2008 to April 2009 (all P < 0.001). Discussion Naturally acquired IFN- γ responses to P. falciparum antigensare short-lived in the absence of repeated P. falciparum infection. Even short periods of malaria interruption may significantly decrease IFN-γ responses to P. falciparum antigens.

Subject/Keywords
Plasmodium falciparum; Interferon gamma; Malaria; Highland Kenya
Publisher
Peer J
Permalink
https://doi.org/10.7717/peerj.2855
http://ir.jooust.ac.ke:8080/xmlui/handle/123456789/2859
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