2-Hydroxy-4-Methoxybenzaldehyde: larvicidal structure-activity studies
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Publication Date
2005Author
Mahanga, Geoffrey M.
Akenga, Teresa O.
Lwande, Wilber
Ndiege, Isaiah O.
Type
ArticleMetadata
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Abstract/ Overview
2-Hydroxy-4-methoxybenzaldehyde (1), a compound isolated from Mondia whytei (Hook) Skeels (Asclepiaceae) roots exhibited larvicidal activity (LD5022 mg/mL). A total of 18 other derivatives and closely related congeners revealed varying levels of larvicidal activity. Several closely related congeners, like 2-benzyloxy-4-methoxybenzaldehyde (2), 2-hydroxybenzaldehyde (12), 2-benzyloxybenzaldehyde (3) and benzylphenyl ether (4), showed marked improvement in activity (LD5010, 9, 4.8, 1.2 mg/mL, respectively) against Anopheles gambiae larvae. 2-Benzoyloxy-4-methoxybenzaldehyde (5) exhibited similar activity level (LD50 28 mg/mL) as 1.
Subject/ Keywords
2-Hydroxy-4-methoxybenzaldehyde; Larvicides; Structure-activity relationships; 2-Hdroxybenzaldehyde; 2-Benzyloxybenzaldehyde; Benzylphenyl ether Anopheles gambiae
Publisher
Chemical Society of EthiopiaISSN
1011-3924Permalink
https://www.ajol.info/index.php/bcse/article/view/21110http://ir.jooust.ac.ke:8080/xmlui/handle/123456789/2912