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dc.contributor.authorErnst, Kacey C
dc.contributor.authorAdoka, Samson O.
dc.contributor.authorKowuor, Dickens O
dc.contributor.authorWilson, Mark L
dc.contributor.authorJohn, Chandy C
dc.date.accessioned2018-11-21T08:48:50Z
dc.date.available2018-11-21T08:48:50Z
dc.date.issued2006
dc.identifier.urihttp://ir.jooust.ac.ke:8080/xmlui/handle/123456789/2937
dc.description.abstractBackground Malaria epidemics in highland areas of East Africa have caused considerable morbidity and mortality in the past two decades. Knowledge of "hotspot" areas of high malaria incidence would allow for focused preventive interventions in resource-poor areas, particularly if the hotspot areas can be discerned during non-epidemic periods and predicted by ecological factors. Methods To address this issue, spatial distribution of malaria incidence and the relationship of ecological factors to malaria incidence were assessed in the highland area of Kipsamoite, Kenya, from 2001–2004. Results Clustering of disease in a single geographic "hotspot" area occurred in epidemic and non-epidemic years, with a 2.6 to 3.2-fold increased risk of malaria inside the hotspot, as compared to outside the area (P < 0.001, all 4 years). Altitude and proximity to the forest were independently associated with increased malaria risk in all years, including epidemic and non-epidemic years. Conclusion In this highland area, areas of high malaria risk are consistent in epidemic and non-epidemic years and are associated with specific ecological risk factors. Ongoing interventions in areas of ecological risk factors could be a cost-effective method of significantly reducing malaria incidence and blunting or preventing epidemics, even in the absence of malaria early warning systems. Further studies should be conducted to see if these findings hold true in varied highland settings.en_US
dc.language.isoenen_US
dc.publisherBMCen_US
dc.subjectMalariaen_US
dc.subjectMalaria Transmissionen_US
dc.subjectMalaria Caseen_US
dc.subjectGeneralize Estimate Equationen_US
dc.subjectEarly Warning Systemen_US
dc.titleMalaria hotspot areas in a highland Kenya site are consistent in epidemic and non-epidemic years and are associated with ecological factorsen_US
dc.typeArticleen_US


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