School of Health Sciences: Recent submissions
Now showing items 101-120 of 190
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Participation of fishing communities in neglected tropical disease/HIV co-infection Cohort Studies in Western Kenya
(2014)Background: Fishing communities on the shores of Lake Victoria are at high risk of schistosome infections, and at the same time, also considered at high risk of HIV infection due to factors associated with lifestyle or ... -
Perennial transmission of malaria in the low altitude areas of Baringo County, Kenya
(BMC, 2017)Background Malaria causes the greatest public health burden in sub-Saharan Africa where high mortality occurs mainly in children under 5 years of age. Traditionally, malaria has been reported mainly in the lowlands endemic ... -
Effect of climatic variability on malaria trends in Baringo County, Kenya
(spring open.com, 2017)Background Malaria transmission in arid and semi-arid regions of Kenya such as Baringo County, is seasonal and often influenced by climatic factors. Unravelling the relationship between climate variables and malaria ... -
CD23b isoform expression in human schistosomiasis identifies a novel subset of activated B cells
(American Society for Microbiology, 2011)Resistance to schistosomiasis is associated with increased levels of serum parasite-specific IgE. IgE exerts its functions through its cellular receptors, FcεRI and FcεRII/CD23; however, its functional significance requires ... -
CD23-Bound IgE augments and dominates recall responses through human Naive B cells
(American association of immunology, 2010)Human peripheral blood BCRμ+ B cells express high levels of CD23 and circulate preloaded with IgE. The Ag specificity of CD23-bound IgE presumably differs from the BCR and likely reflects the Ag-specific mix of free serum ... -
Human schistosomiasis is associated with endotoxemia and toll-like receptor 2- and 4-Bearing B Cells
(The American Society of Tropical Medicine and Hygiene, 2010)Schistosomiasis is caused by parasitic trematodes. Individuals can accumulate hundreds of intravascular worms, which secrete a myriad of antigenic molecules into the bloodstream. Some of these molecules suppress immunity ... -
Decline in childhood iron deficiency after interruption of malaria transmission in highland Kenya1–3
(AJCN, 2014-07-30)Background: Achieving optimal iron status in children in malariaendemic areas may increase the risk of malaria. Malaria itself may contribute to iron deficiency, but the impact of an interruption in malaria transmission ... -
The Plasmodium falciparum antigen MB2 induces interferon-γ and interleukin-10 responses in adults in malaria endemic areas of Western Kenya
(PMC, 2013)Background: MB2 is a novel Plasmodium falciparum antigen of unknown function expressed in pre-erythrocytic and blood stages of infection in the human host. Interferon-gamma (IFN-γ) and interleukin (IL)-10 responses to ... -
Decrease in numbers of naive and resting B cells in HIV-infected Kenyan adults leads to a proportional increase in total and Plasmodium falciparum–specific atypical memory B cells
(The American Association of Immunologists, Inc., 2017-05-19)Human immunodeficiency virus type 1 (HIV-1) infection is associated with B cell activation and exhaustion, and hypergammaglobulinemia. How these changes influence B cell responses to coinfections such as malaria is poorly ... -
Impact of land use on the distribution and diversity of entomopathogenic nematodes in Embu and Taita Districts, Kenya
(Tropical and Subtropical Agroecosystems, 2010)Natural entomopathogenic nematodes(EPNs) are considered as potential biological control agents against soil-borne insect pests. This study was conducted to determine the impact of land use on the distribution occurrence ... -
Successful global health research partnerships: What makes them work?
(The American Society of Tropical Medicine and Hygiene, 2016-01)There are many successful global health research partnerships, but little information is available about what makes them successful. We asked 14 research colleagues from Uganda, Kenya, and the United States who have extensive ... -
Decreased prevalence of anemia in highland areas of low malaria transmission after a 1-Year interruption of transmission
(Oxford University Press, 2011-11-03)Background. Malaria control campaigns have reduced malaria transmission to very low levels in many areas of Africa. Yet the extent to which malaria interruption or elimination might decrease the prevalence of anemia in ... -
An ethnic-specific polymorphism in the catalytic subunit of glutamate-cysteine ligase impairs the production of glutathione intermediates in vitro
(ScienceDirect, 2010-09)Glutathione plays a crucial role in free radical scavenging, oxidative injury, and cellular homeostasis. Previously, we identified a non-synonymous polymorphism (P462S) in the gene encoding the catalytic subunit of ... -
Standardization and validation of a cytometric bead assay to assess antibodies to multiple Plasmodium falciparum recombinant antigens
(BioMed Central Ltd, 2012-12-21)Background Multiplex cytometric bead assay (CBA) have a number of advantages over ELISA for antibody testing, but little information is available on standardization and validation of antibody CBA to multiple Plasmodium ... -
Evaluating parental screening tool for developmental milestone in children under five years in rural Western Kenya
(International Journal of Scientific and Research Publications, 2017-07)Background: An estimated 200 million children suffer from developmental delays, most in developing countries. Early diagnosis through screening is key to timely intervention. However, screening tools have not been assessed ... -
The isolation of leishmanial parasites from domestic goats and wild hosts in Kenya and the possible role of goats as reservoirs of leishmaniases
(International Journal of Tropical Insect Science, 2011-09-01)Screening of leishmanial parasites from domestic and wild animals was carried out in Kacheliba, West Pokot District. Spleens and livers of the animals were cultured in NNN diphasic medium. Thin smears of the same tissues ... -
Laboratory tests of oviposition by the African malaria mosquito, Anopheles gambiae, on dark soil as influenced by presence or absence of vegetation
(BMC, 2006-10-12)Background Physical objects like vegetation can influence oviposition by mosquitoes on soil or water substrates. Anopheles gambiae s. l. is generally thought to utilize puddles over bare soil as its prime larval habitat ... -
Comparative study of aminosidine, etophamide and nimorazole, alone or in combination, in the treatment of intestinal amoebiasis in Kenya
(SpringerLink, 1990-05-26)417 patients suffering from intestinal amoebiasis were randomly allocated to 6 different treatment groups in a controlled study in 3 District Hospitals in Kenya. The patients received either aminosidine (A), etophamide ... -
The efficacy of 22,23-dihydroavermectin B1 (ivermectin) acting singly or in combination with a benzodiazepine on microfilariae of Onchocerca species and Brugia pahangi (an in vitro study)
(ELSEVIER, 1989-07)An in vitro study of the antinematodal action of two groups of compounds which act on the receptor complex of the inhibitory neurotransmitter, Gamma-aminobutyric acid (GAGA) in mammalian systems is described. The compounds, ... -
HIV and cervical cancer in Kenya
(International Journal of Gynecology and Obstetrics, 2002-01)Objectives: To determine the effect of the HIV epidemic on invasive cervical cancer in Kenya. Methods: Of the 3902 women who were diagnosed with reproductive tract malignancies at Kenyatta National Hospital (KNH) from 1989 ...
