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Analgesics from Lonchocarpus eriocalyx Harms

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TPR_Volume 2_Issue 4_Pages 253-260(1).pdf (401.6Kb)
Publication Date
2018-12-13
Author
Ochung, Angeline A.
Owuor, Phillip O.
Manguro, Lawrence A.O.
Ismael, Ishola O.
Nyunja, Regina A.
Ochieng, Charles O.
Opiyo, Sylvia A.
Type
Article
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Abstract/Overview

Four lupane-type terpenoids, namely lupeol (1), friedelin (2), stigmasterol (3), and stigmasterol-3-O-glucoside (4) were isolated from the ethyl acetate extract of leaves of Lonchocarpus eriocalyx Harms. These compounds were obtained by extensive silica gel chromatography and their structures elucidated by 1D and 2D nuclear magnetic resonance (NMR) as well as comparison with literature data. The ethyl acetate, dichloromethane and methanol extracts (100 mg/Kg) had a pretreatment latency of 3.1±0.15, 3.0±0.01 and 3.5±0.12 at the zero minute. The post latency of 6.4±0.13 was observed for ethyl acetate at 30 minutes which confirmed its effectiveness to halt pain, while compounds 1 and 2had pretreatment latency of 3.1±0.12 and 3.2±0.12, respectively. The isolated compounds from this medicinal plant along with their analgesic activity have been reported for the first time.

Subject/Keywords
Analgesic activity; Fabaceae; Leaves; Lonchocarpus eriocalyx Harms; Terpenoids
Publisher
Islamic Azad University, Shahrood Branch Press,
Series
Trends in Phytochemical Research (TPR);
Permalink
http://tpr.iau-shahrood.ac.ir
http://ir.jooust.ac.ke:8080/xmlui/handle/123456789/7978
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