Browsing by Author "John, Chandy C"
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Antibody Correlates of Protection from Clinical Plasmodium Falciparum Malaria in an Area of Low and Unstable Malaria Transmission
Hamre, Karen ES; Ondigo, Bartholomew N; Hodges, James S; Dutta, Sheetij; Theisen, Michael; Ayodo, George; John, Chandy C (The American Society of Tropical Medicine and Hygiene, 2020-12-02)Immune correlates of protection against clinical malaria are difficult to ascertain in low-transmission areas because of the limited number of malaria cases. We collected blood samples from 5,753 individuals in a Kenyan ... -
Antibody Profiles to P. falciparum Antigens over Time Characterize Acute and Long-Term Malaria Exposure in an Area of Low and Unstable Transmission
Ondigo, Bartholomew N; Hamre, Karen ES; Frosch, Anne EP; Ayodo, George; White, Michael T; John, Chandy C (The American Society of Tropical Medicine and Hygiene, 2020-12-02)Prevalence and levels of antibodies to multiple Plasmodium falciparum antigens show promise as tools for estimating malaria exposure. In a highland area of Kenya with unstable transmission, we assessed the presence and ... -
Lack of Consistent Malaria Incidence Hotspots in a Highland Kenyan Area during a 10-Year Period of Very Low and Unstable Transmission
Hamre, Karen; Hodges, James; Ayodo, George; John, Chandy C (The American Society of Tropical Medicine and Hygiene, 2020-12-02)The use of spatial data in malaria elimination strategies is important to understand whether targeted interventions against malaria can be used, particularly in areas with limited resources. We previously documented ... -
Malaria hotspot areas in a highland Kenya site are consistent in epidemic and non-epidemic years and are associated with ecological factors
Ernst, Kacey C; Adoka, Samson O.; Kowuor, Dickens O; Wilson, Mark L; John, Chandy C (BMC, 2006)Background Malaria epidemics in highland areas of East Africa have caused considerable morbidity and mortality in the past two decades. Knowledge of "hotspot" areas of high malaria incidence would allow for focused ... -
A mass insecticide-treated bed net distribution campaign reduced malaria risk on an individual but not population level in a highland epidemic-prone area of Kenya
Hamre, Karen ES; Ayodo, George; Hodges, James S; John, Chandy C (The American Society of Tropical Medicine and Hygiene, 2020-12-02)In epidemic-prone areas of the western highlands, the Kenya Ministry of Health conducted campaigns of indoor residual spraying (IRS) of households, followed by mass distribution of insecticide-treated bed nets (ITNs), as ...