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Interferon-γ responses to Plasmodium falciparum vaccine candidate antigens decrease in the absence of malaria transmission
(Peer J, 2017-01-10)
Background
Malaria elimination campaigns are planned or active in many countries. The effects of malaria elimination on immune responses such as antigen-specific IFN- γ responses are not well characterized.
Methods
IFN- ...
Standardization and validation of a cytometric bead assay to assess antibodies to multiple Plasmodium falciparum recombinant antigens
(BioMed Central Ltd, 2012-12-21)
Background
Multiplex cytometric bead assay (CBA) have a number of advantages over ELISA for antibody testing, but little information is available on standardization and validation of antibody CBA to multiple Plasmodium ...
Decreased prevalence of anemia in highland areas of low malaria transmission after a 1-Year interruption of transmission
(Oxford University Press, 2011-11-03)
Background. Malaria control campaigns have reduced malaria transmission to very low levels in many areas of Africa. Yet the extent to which malaria interruption or elimination might decrease the prevalence of anemia in ...
Sensitivity of fever for diagnosis of clinical malaria in a Kenyan area of unstable, low malaria transmission
(BMC, 2014-04-30)
Background
Malaria in highland areas of Kenya affects children and adults. Local clinicians include symptoms other than fever when screening for malaria because they believe that fever alone does not capture all cases of ...
An ethnic-specific polymorphism in the catalytic subunit of glutamate-cysteine ligase impairs the production of glutathione intermediates in vitro
(ScienceDirect, 2010-09)
Glutathione plays a crucial role in free radical scavenging, oxidative injury, and cellular homeostasis. Previously, we identified a non-synonymous polymorphism (P462S) in the gene encoding the catalytic subunit of ...
The Plasmodium falciparum antigen MB2 induces interferon-γ and interleukin-10 responses in adults in malaria endemic areas of Western Kenya
(PMC, 2013)
Background:
MB2 is a novel Plasmodium falciparum antigen of unknown function expressed in pre-erythrocytic and blood stages of infection in the human host. Interferon-gamma (IFN-γ) and interleukin (IL)-10 responses to ...