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Sickle cell trait (HbAS) is associated with increased expression of erythrocyte complement regulatory proteins CR1 and CD55 levels in children
(International Journal of TROPICAL DISEASE & Health, 2013)
Aims: Erythrocyte complement regulatory proteins, complement receptor 1 (CR1) and decay accelerating factor (CD55) protect red blood cells (RBCs) from complement mediated damage by controlling complement activation cascade ...
Increased complement deposition on red blood cells in children with sickle cell trait
(BJMMR, 2015)
Aims: Immune-mediated mechanism, such as deposition of complement (C3b) on erythrocytes leading to enhanced receptor-mediated uptake by macrophages has been proposed to contribute
partly to the destruction of non-infected ...
Association between sickle cell trait and low density parasitaemia among asymptomatic and parasitaemic individuals living in P. falciparum malaria Holoendemic region of Western Kenya.
(SDI, 2008)
The frequency of the mutant gene for sickle cell is widely distributed in the sub-Saharan
Africa, the Middle East and the Indian subcontinent. There is epidemiologic evidence that
sickle cell trait confers a survival ...