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Changes in b cell populations and Merozoite surface protein-1-specific memory b cell responses after prolonged absence of detectable p. falciparum infection
(PLOS, 2013-05)
Clinical immunity to malaria declines in the absence of repeated parasite exposure. However, little is known about how B cell populations and antigen-specific memory B cells change in the absence of P. falciparum infection. ...
Evolution of the primate trypanolytic factor APOL1
(PNAS, 2014-04-08)
ApolipoproteinL1 (APOL1) protects humans and some primates against several African trypanosomes. APOL1 genetic variants strongly associated with kidney disease in African Americans have additional trypanolytic activity ...
Experience and perceptions on preterm births among women attending ANC Clinic at Kisumu County Hospital, Kenya
(Researchjournali’s Journal of Public Health, 2018-03)
Preterm birth is one of the main causes of neonatal death, and it is now the second leading cause of death after
pneumonia in children under the age of five. Kenya is estimated to have 12.3% preterm births and 22 ...
Evaluating parental screening tool for developmental milestone in children under five years in rural Western Kenya
(International Journal of Scientific and Research Publications, 2017-07)
Background: An estimated 200 million children suffer from developmental delays, most in developing countries. Early diagnosis through screening is key to timely intervention. However, screening tools have not been assessed ...
Factors associated with non-adherence to Artemisinin-based combination therapy (ACT) to malaria in a rural population from holoendemic region of western Kenya
(BMC Infectious Diseases, 2012-06-24)
Background
Over the years, reports implicate improper anti-malarial use as a major contributor of morbidity and mortality amongst millions of residents in malaria endemic areas, Kenya included. However, there are limited ...
Global diversity, population stratification, and selection of human copy-number variation
(Science, 2015-09-11)
In order to explore the diversity and selective signatures of duplication and deletion human copy-number variants (CNVs), we sequenced 236 individuals from 125 distinct human populations. We observed that duplications ...
Interferon-γ responses to Plasmodium falciparum vaccine candidate antigens decrease in the absence of malaria transmission
(Peer J, 2017-01-10)
Background
Malaria elimination campaigns are planned or active in many countries. The effects of malaria elimination on immune responses such as antigen-specific IFN- γ responses are not well characterized.
Methods
IFN- ...
Standardization and validation of a cytometric bead assay to assess antibodies to multiple Plasmodium falciparum recombinant antigens
(BioMed Central Ltd, 2012-12-21)
Background
Multiplex cytometric bead assay (CBA) have a number of advantages over ELISA for antibody testing, but little information is available on standardization and validation of antibody CBA to multiple Plasmodium ...
Decreased prevalence of anemia in highland areas of low malaria transmission after a 1-Year interruption of transmission
(Oxford University Press, 2011-11-03)
Background. Malaria control campaigns have reduced malaria transmission to very low levels in many areas of Africa. Yet the extent to which malaria interruption or elimination might decrease the prevalence of anemia in ...
Sensitivity of fever for diagnosis of clinical malaria in a Kenyan area of unstable, low malaria transmission
(BMC, 2014-04-30)
Background
Malaria in highland areas of Kenya affects children and adults. Local clinicians include symptoms other than fever when screening for malaria because they believe that fever alone does not capture all cases of ...