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Pathogenicity of Trichomonas hominis in Kenya

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Publication Date
1988-08
Author
Estambale, Benson B.
Chunge, CN.
Pamba, HO
Munanga, P.
Kangethe, S.
Type
Article
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Abstract/Overview

An in vitro study of the antinematodal action of two groups of compounds which act on the receptor complex of the inhibitory neurotransmitter, Gamma-aminobutyric acid (GABA) in mammalian systems is described. The compounds, Ivermectin and two benzodiazepines, Diazepam and a water soluble Midazolam were tested singly or in combination against two microfilarial parasites Onchocerca lienalis (closely related to Onchocerca volvulus) and Brugia pahangi. The combination of ivermectin and diazepam at a concentration of 0.1 microgram/ml and 33 micrograms/ml respectively achieved the same effect on microfilarial motility as when ivermectin was given at 1 microgram/ml alone or diazepam at 66 micrograms/ml alone. Similarly when the combination of ivermectin at 0.1 microgram/ml and midazolam at 10 micrograms/ml was used it achieved the same effect as ivermectin at 1 microgram/ml alone or midazolam at 33 micrograms/ml alone. This showed that both benzodiazepines had a synergistic effect on the activity of ivermectin. The microfilariae of B. pahangi were insensitive to both groups of compounds at all concentrations used.

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https://profiles.uonbi.ac.ke/bestambale/publications/pathogenicity-trichomonas-hominis-kenya-east-afr-med-j-1988-aug658532-4
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http://ir.jooust.ac.ke:8080/xmlui/handle/123456789/1267
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