dc.contributor.author |
Estambale, Benson B. |
|
dc.contributor.author |
Chunge, CN. |
|
dc.contributor.author |
Pamba, HO |
|
dc.contributor.author |
Munanga, P. |
|
dc.contributor.author |
Kangethe, S. |
|
dc.date.accessioned |
2018-06-12T08:11:18Z |
|
dc.date.available |
2018-06-12T08:11:18Z |
|
dc.date.issued |
1988-08 |
|
dc.identifier.issn |
https://profiles.uonbi.ac.ke/bestambale/publications/pathogenicity-trichomonas-hominis-kenya-east-afr-med-j-1988-aug658532-4 |
|
dc.identifier.uri |
http://ir.jooust.ac.ke:8080/xmlui/handle/123456789/1267 |
|
dc.description.abstract |
An in vitro study of the antinematodal action of two groups of compounds which act on the receptor complex of the inhibitory neurotransmitter, Gamma-aminobutyric acid (GABA) in mammalian systems is described. The compounds, Ivermectin and two benzodiazepines, Diazepam and a water soluble Midazolam were tested singly or in combination against two microfilarial parasites Onchocerca lienalis (closely related to Onchocerca volvulus) and Brugia pahangi. The combination of ivermectin and diazepam at a concentration of 0.1 microgram/ml and 33 micrograms/ml respectively achieved the same effect on microfilarial motility as when ivermectin was given at 1 microgram/ml alone or diazepam at 66 micrograms/ml alone. Similarly when the combination of ivermectin at 0.1 microgram/ml and midazolam at 10 micrograms/ml was used it achieved the same effect as ivermectin at 1 microgram/ml alone or midazolam at 33 micrograms/ml alone. This showed that both benzodiazepines had a synergistic effect on the activity of ivermectin. The microfilariae of B. pahangi were insensitive to both groups of compounds at all concentrations used. |
en_US |
dc.language.iso |
en |
en_US |
dc.title |
Pathogenicity of Trichomonas hominis in Kenya |
en_US |
dc.type |
Article |
en_US |