| dc.contributor.author | Estambale, Benson B. | |
| dc.contributor.author | Chunge, CN. | |
| dc.contributor.author | Pamba, HO | |
| dc.contributor.author | Munanga, P. | |
| dc.contributor.author | Kangethe, S. | |
| dc.date.accessioned | 2018-06-12T08:11:18Z | |
| dc.date.available | 2018-06-12T08:11:18Z | |
| dc.date.issued | 1988-08 | |
| dc.identifier.issn | https://profiles.uonbi.ac.ke/bestambale/publications/pathogenicity-trichomonas-hominis-kenya-east-afr-med-j-1988-aug658532-4 | |
| dc.identifier.uri | http://ir.jooust.ac.ke:8080/xmlui/handle/123456789/1267 | |
| dc.description.abstract | An in vitro study of the antinematodal action of two groups of compounds which act on the receptor complex of the inhibitory neurotransmitter, Gamma-aminobutyric acid (GABA) in mammalian systems is described. The compounds, Ivermectin and two benzodiazepines, Diazepam and a water soluble Midazolam were tested singly or in combination against two microfilarial parasites Onchocerca lienalis (closely related to Onchocerca volvulus) and Brugia pahangi. The combination of ivermectin and diazepam at a concentration of 0.1 microgram/ml and 33 micrograms/ml respectively achieved the same effect on microfilarial motility as when ivermectin was given at 1 microgram/ml alone or diazepam at 66 micrograms/ml alone. Similarly when the combination of ivermectin at 0.1 microgram/ml and midazolam at 10 micrograms/ml was used it achieved the same effect as ivermectin at 1 microgram/ml alone or midazolam at 33 micrograms/ml alone. This showed that both benzodiazepines had a synergistic effect on the activity of ivermectin. The microfilariae of B. pahangi were insensitive to both groups of compounds at all concentrations used. | en_US |
| dc.language.iso | en | en_US |
| dc.title | Pathogenicity of Trichomonas hominis in Kenya | en_US |
| dc.type | Article | en_US |
