Prevention of anaemia in pregnancy using insecticide-treated bednets and sulfadoxine-pyrimethamine in a highly malarious area of Kenya: a randomized controlled trial

Show simple item record

dc.contributor.author Njagi, Joseph Kiambo
dc.contributor.author Magnussen, Pascal
dc.contributor.author Estambale, Benson B.
dc.contributor.author Ouma, John
dc.contributor.author Mugo, Benbolt
dc.date.accessioned 2018-06-20T07:13:13Z
dc.date.available 2018-06-20T07:13:13Z
dc.date.issued 2003-05
dc.identifier.uri https://doi.org/10.1016/S0035-9203(03)90141-6
dc.identifier.uri http://ir.jooust.ac.ke:8080/xmlui/handle/123456789/1283
dc.description.abstract To compare the effects of intermittent treatment with sulfadoxine-pyrimethamine (SP) given during the second and third trimester of pregnancy, the use of insecticide-treated nets (ITN), or the combination of both on haemoglobin (Hb) levels during pregnancy, a randomized, placebo-controlled intervention trial was conducted in a malaria-endemic area of western Kenya from July 1997 to September 1999. Primigravidae and secundigravidae were enrolled into the study and randomized into 4 intervention groups: (i) ITNs and SP, (ii) ITNs and placebo SP, (iii) SP alone, and (iv) placebo SP. All groups were offered case management and iron and folic acid supplementation. Seven hundred and fifty-two women were followed until delivery (53.2% were primigravidae and 46.8% secundigravidae). Among primigravidae in all the groups there was a significant improvement in Hb levels at delivery (107.6 g/L) compared with recruitment (101.9 g/L) (P < 0.006) with the greatest improvement in the combination ITNs + SP group. The protective efficacy of ITNs + SP on anaemia was 55.8% (95% CI 30.6−71.8), of SP alone 50.9% (95% CI 22.2−69.0), and of ITNs 41.6% (95% CI 9.8−62.3). Among secundigravidae, Hb levels were slightly lower at delivery compared with recruitment (P = 0.03). It was concluded that malaria is a major cause of anaemia in primigravidae but that other causes play a more significant role in secundigravidae, and that intermittent treatment with SP or use of ITNs benefits primigravidae more than secundigravidae. en_US
dc.language.iso en en_US
dc.publisher Elsevier en_US
dc.subject Malaria en_US
dc.subject Anaemia en_US
dc.subject Pregnancy en_US
dc.subject Primigravidae en_US
dc.subject Secundigravidae en_US
dc.subject Prevention en_US
dc.subject Control en_US
dc.subject Insecticide-treated nets en_US
dc.subject Sulfadoxine-pyrimethamine en_US
dc.subject Kenya en_US
dc.title Prevention of anaemia in pregnancy using insecticide-treated bednets and sulfadoxine-pyrimethamine in a highly malarious area of Kenya: a randomized controlled trial en_US
dc.type Article en_US


Files in this item

This item appears in the following Collection(s)

Show simple item record

Search DSpace


Advanced Search

Browse

My Account