Red blood cell immune complex binding capacity in children with sickle cell trait (HBAS) living in p. falciparum malaria holoendemic region of Western Kenya
View/ Open
Publication Date
2012Author
Otieno, Walter
Estambale, Benson B.
Odera, Michael M.
Aluoch, Joash R.
Stoute, José A.
Type
ArticleMetadata
Show full item record
Abstract/ Overview
Malaria infection leads to the formation of circulating immune complexes (CICs) which have been implicated in the pathogenesis of complicated malaria which includes severe malarial anemia. Children with sickle cell trait (HbAS) are less predisposed to getting severe manifestations of malaria. We carried out a study to determine the competence of the red blood cells (RBCs) of children with HbAS to bind immune complexes (ICs) and compared this with normal hemoglobin (HbAA).
Subject/ Keywords
Immunity; Plasmodium Falciparum; Anemias; Assaying; Children; Deoxygenation; Erythrocytes; Kenya; Malaria; Pathogenesis; Receptor Sites(Physiology); Sickle Cells
Further Details
http://www.dtic.mil/dtic/tr/fulltext/u2/a571728.pdf
Publisher
IJTDHPermalink
http://www.dtic.mil/dtic/tr/fulltext/u2/a571728.pdfhttp://ir.jooust.ac.ke:8080/xmlui/handle/123456789/1341