Show simple item record

dc.contributor.authorOwino, Victor O.
dc.contributor.authorSkau, Jutta
dc.contributor.authorOmollo, Selina
dc.contributor.authorKonyole, Silvenus
dc.contributor.authorKinyuru, John
dc.contributor.authorEstambale, Benson B.
dc.contributor.authorOwuor, Bethwel
dc.contributor.authorNanna, Roos
dc.contributor.authorFriis, Henrik
dc.date.accessioned2018-09-19T07:52:28Z
dc.date.available2018-09-19T07:52:28Z
dc.date.issued2015
dc.identifier.urihttp://journals.sagepub.com/doi/pdf/10.1177/15648265150361S107
dc.identifier.urihttp://ir.jooust.ac.ke:8080/xmlui/handle/123456789/1538
dc.description.abstractBackground. Researchers face myriad challenges in the design and implementation of randomized, controlled trials. Apart from summaries on limitations, these challenges are rarely documented in detail to inform future research projects. Objective. To describe methodological challenges encountered during randomized, controlled trials (WinFood Study) designed to assess the efficacy of locally produced complementary foods based on traditional animal-source foods (edible termites and spiders) to support growth and nutritional status in Kenyan and Cambodian infants. Methods. In a randomized, controlled design, infants received WinFood or corn–soy blend (CSB) for 9 months from 6 to 15 months of age. Lean mass accrual and blood nutrition indicators (lipid profile, iron and zinc status) were measured cross-sectionally at 9 and 15 months of age, respectively. Lean mass was determined by measuring deuterium oxide enrichment in saliva samples following a standard dose of deuterium solution (0.5 g/kg body weight) to infants. Blood nutrition indicators were determined following the drawing of 3 mL of blood by venipuncture. Results. Challenges included rapid depletion of food rations, high rate of loss to follow-up, delayed ethical approval, lack of local food-processing capacity, low capacity among staff to draw blood, and lack of laboratory capacity to perform both deuterium oxide and micronutrient status measurements. Spillage of deuterium oxide solution during dosing was a major challenge in the Kenya context. A high rate of morbidity among infants made some assessments very difficult, especially drawing of blood and saliva samples. Conclusions. The challenges were largely contextual. Improvement of local laboratory capacity, training of staff, and sensitization of the communities and the Ethics Review Committee are highly recommended.en_US
dc.language.isoenen_US
dc.subjectCambodiaen_US
dc.subjectfield challengesen_US
dc.subjectKenyaen_US
dc.subjectrandomizeden_US
dc.subjectcontrolled trialen_US
dc.subjectWinFooden_US
dc.titleWinFood data from Kenya and Cambodia: Constraints on field proceduresen_US
dc.typeWorking Paperen_US


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record