| dc.contributor.author | Estambale, Benson B. | |
| dc.contributor.author | Howells, R.E. | |
| dc.date.accessioned | 2018-11-12T06:15:22Z | |
| dc.date.available | 2018-11-12T06:15:22Z | |
| dc.date.issued | 1989-07 | |
| dc.identifier.uri | https://doi.org/10.1016/S0934-8840(89)80080-5 | |
| dc.identifier.uri | http://ir.jooust.ac.ke:8080/xmlui/handle/123456789/2616 | |
| dc.description.abstract | An in vitro study of the antinematodal action of two groups of compounds which act on the receptor complex of the inhibitory neurotransmitter, Gamma-aminobutyric acid (GAGA) in mammalian systems is described.
The compounds, Ivermectin and two benzodiazepines, Diazepam and a water soluble Midazolam were tested singly or in combination against two microfilarial parasites Onchocerca lienalis (closely related to Onchocerca volvulus) and Brugia pahangi.
The combination of ivermectin and diazepam at a concentration of 0.1 µg/ml and 33 µg/ml respectively achieved the same effect on microfilarial motility as when ivermectin was given at 1 µg/ml alone or diazepam at 66 µg/ml alone. Similarly, when the combination of ivermectin at 0.1 µg/ml and midazolam at 10 µg/ml was used it achieved the same effect as ivermectin at 1 µg/ml alone or midazolam at 33 µg/ml alone. This showed that both benzodiazepines had a synergistic effect on the activity of ivermectin.
The microfilariae of B. pahangi were insensitive to both groups of compounds at all concentrations used. | en_US |
| dc.language.iso | en | en_US |
| dc.publisher | ELSEVIER | en_US |
| dc.title | The efficacy of 22,23-dihydroavermectin B1 (ivermectin) acting singly or in combination with a benzodiazepine on microfilariae of Onchocerca species and Brugia pahangi (an in vitro study) | en_US |
| dc.type | Other | en_US |
