| dc.contributor.author | Frosch, Anne E. | |
| dc.contributor.author | Odumade, Oludare A. | |
| dc.contributor.author | Taylor, Justin J. | |
| dc.contributor.author | Ireland, Kathleen | |
| dc.contributor.author | Ayodo, George | |
| dc.contributor.author | Ondigo, Bartholomew | |
| dc.contributor.author | Narum, David L. | |
| dc.contributor.author | Vulule, John | |
| dc.contributor.author | John, Chandy C. | |
| dc.date.accessioned | 2018-11-19T07:19:02Z | |
| dc.date.available | 2018-11-19T07:19:02Z | |
| dc.date.issued | 2017-05-19 | |
| dc.identifier.issn | P-0022-1767 | |
| dc.identifier.issn | E-1550-6606 | |
| dc.identifier.uri | https://doi.org/10.4049/jimmunol.1600773 | |
| dc.identifier.uri | http://ir.jooust.ac.ke:8080/xmlui/handle/123456789/2855 | |
| dc.description.abstract | Human immunodeficiency virus type 1 (HIV-1) infection is associated with B cell activation and exhaustion, and hypergammaglobulinemia. How these changes influence B cell responses to coinfections such as malaria is poorly understood. To address this, we compared B cell phenotypes and Abs specific for the Plasmodium falciparum vaccine candidate apical membrane Ag-1 (AMA1) in HIV-infected and uninfected adults living in Kenya. Surprisingly, HIV-1 infection was not associated with a difference in serum AMA1-specific Ab levels. HIV-infected individuals had a higher proportion of total atypical and total activated memory B cells (MBCs). Using an AMA1 tetramer to detect AMA1-specific B cells, HIV-infected individuals were also shown to have a higher proportion of AMA1-specific atypical MBCs. However, this proportional increase resulted in large part from a loss in the number of naive and resting MBCs rather than an increase in the number of atypical and activated cells. The loss of resting MBCs and naive B cells was mirrored in a population of cells specific for an Ag to which these individuals were unlikely to have been chronically exposed. Together, the data show that changes in P. falciparum Ag–specific B cell subsets in HIV-infected individuals mirror those in the overall B cell population, and suggest that the increased proportion of atypical MBC phenotypes found in HIV-1–infected individuals results from the loss of naive and resting MBCs. | en_US |
| dc.language.iso | en | en_US |
| dc.publisher | The American Association of Immunologists, Inc. | en_US |
| dc.title | Decrease in numbers of naive and resting B cells in HIV-infected Kenyan adults leads to a proportional increase in total and Plasmodium falciparum–specific atypical memory B cells | en_US |
| dc.type | Article | en_US |
