| dc.contributor.author | Ayieko, Cyrus | |
| dc.contributor.author | Ogola, Bilha S. | |
| dc.contributor.author | Ochola, Lyticia | |
| dc.contributor.author | Ngwena, Gideon A.M. | |
| dc.contributor.author | Ayodo, George | |
| dc.contributor.author | Hodges, James S. | |
| dc.contributor.author | Noland, Gregory S. | |
| dc.contributor.author | John, Chandy C. | |
| dc.date.accessioned | 2018-11-19T07:40:41Z | |
| dc.date.available | 2018-11-19T07:40:41Z | |
| dc.date.issued | 2017-01-10 | |
| dc.identifier.citation | Ayieko C, Ogola BS, Ochola L, Ngwena GAM, Ayodo G, Hodges JS, Noland GS, John CC. 2017. Interferon-γ responses to Plasmodium falciparum vaccine candidate antigens decrease in the absence of malaria transmission. PeerJ 5:e2855 | en_US |
| dc.identifier.uri | https://doi.org/10.7717/peerj.2855 | |
| dc.identifier.uri | http://ir.jooust.ac.ke:8080/xmlui/handle/123456789/2859 | |
| dc.description.abstract | Background
Malaria elimination campaigns are planned or active in many countries. The effects of malaria elimination on immune responses such as antigen-specific IFN- γ responses are not well characterized.
Methods
IFN- γ responses to the P. falciparum antigens circumsporozoite protein, liver stage antigen-1, thrombospondin-related adhesive protein, apical membrane antigen-1, MB2, and merozoite surface protein-1 were tested by ELISA in 243 individuals in highland Kenya in April 2008, October 2008, and April 2009, after a one-year period of interrupted malaria transmission from April 2007 to March 2008.
Results
While one individual (0.4%) tested positive for P. falciparum by PCR inOctober 2008 and another two (0.9%) tested positive in April 2009, no clinical malaria cases were detected during weekly visits. Levels of IFN-γ to all antigens decreased significantly from April 2008 to April 2009 (all P < 0.001).
Discussion
Naturally acquired IFN- γ responses to P. falciparum antigensare short-lived in the absence of repeated P. falciparum infection. Even short periods of malaria interruption may significantly decrease IFN-γ responses to P. falciparum antigens. | en_US |
| dc.description.sponsorship | National Institute of Allergy and Infectious
Diseases ;
Fogarty International Center | en_US |
| dc.language.iso | en | en_US |
| dc.publisher | Peer J | en_US |
| dc.subject | Plasmodium falciparum | en_US |
| dc.subject | Interferon gamma | en_US |
| dc.subject | Malaria | en_US |
| dc.subject | Highland Kenya | en_US |
| dc.title | Interferon-γ responses to Plasmodium falciparum vaccine candidate antigens decrease in the absence of malaria transmission | en_US |
| dc.type | Article | en_US |
