Browsing School of Health Sciences by Title
Now showing items 22-41 of 181
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CD23-Bound IgE augments and dominates recall responses through human Naive B cells
(American association of immunology, 2010)Human peripheral blood BCRμ+ B cells express high levels of CD23 and circulate preloaded with IgE. The Ag specificity of CD23-bound IgE presumably differs from the BCR and likely reflects the Ag-specific mix of free serum ... -
CD23b isoform expression in human schistosomiasis identifies a novel subset of activated B cells
(American Society for Microbiology, 2011)Resistance to schistosomiasis is associated with increased levels of serum parasite-specific IgE. IgE exerts its functions through its cellular receptors, FcεRI and FcεRII/CD23; however, its functional significance requires ... -
Changes in b cell populations and Merozoite surface protein-1-specific memory b cell responses after prolonged absence of detectable p. falciparum infection
(PLOS, 2013-05)Clinical immunity to malaria declines in the absence of repeated parasite exposure. However, little is known about how B cell populations and antigen-specific memory B cells change in the absence of P. falciparum infection. ... -
Characterizing Nosocomial Bacterial Pathogens and Antibiotic Resistance at a Major Referral Hospital in Western Kenya
(International Journal of Public Health and Epidemiology Research, 2023)Bacterial pathogens responsible for hospital acquired infections in Jaramogi Oginga Odinga Teaching and Referral Hospital are difficult to treat due to their tendency to resist most antibiotics used against them. This study ... -
Clinical and Host Related Factors Influencing Prevalence of Tuberculosis in Bumula Sub County, Bungoma County in Kenya
(Academia, 2019-07-07)Robert Shihuzire Magomere, , Tuberculosis (TB) is an infectious bacterial disease caused by bacillus Mycobacterium tuberculosis. Globally 9.6 million people fell ill with TB and 1.5 million died from the disease in 2014. ... -
Combining evidence of natural selection with association analysis increases power to detect malaria-resistance variants
(The American Society of Human Genetics, 2007-08)Statistical power to detect disease variants can be increased by weighting candidates by their evidence of natural selection. To demonstrate that this theoretical idea works in practice, we performed an association study ... -
Community perceptions and attitudes on malaria case management and the role of community health workers
(Springer Nature, 2017-07-04)Background Community Case Management of malaria (CCMm) is one of the new approaches adopted by the World Health Organization for malaria endemic countries to reduce the burden of malaria for vulnerable populations. It is ... -
Community Perceptions on Maternal Health Service Provision in Lunga Lunga Sub County in Kwale County-Kenya
(World Journal of Innovative Research, 2020-05)Maternal and neonatal morbidity and mortality are major public health concerns in most developing countries and in under resourced settings. Provision of safe motherhood is of utmost importance in the reduction of maternal ... -
Comorbidities Associated with Increased Risk of Death among Children Aged 2-59 Months with Severe Pneumonia in Western Kenya
(African Journal of Health Sciences, 2023-05-19)Globally, severe pneumonia remains the leading infectious cause of death in children younger than 5 years. Comorbidities increase the risk of death among children with severe pneumonia across age groups and regions; however, ... -
Comparative study of aminosidine, etophamide and nimorazole, alone or in combination, in the treatment of intestinal amoebiasis in Kenya
(SpringerLink, 1990-05-26)417 patients suffering from intestinal amoebiasis were randomly allocated to 6 different treatment groups in a controlled study in 3 District Hospitals in Kenya. The patients received either aminosidine (A), etophamide ... -
Comparison of four nitroimidazole compounds for treatment of symptomatic amoebiasis in Kenya.
(PubMed, 1989)Four antiamoebic drugs currently used in many Kenyan hospitals and health centres were compared for their efficacy on symptomatic luminal amoebiasis in Kiambu, Kilifi, and Machakos hospitals during this study. The drugs ... -
The Cost Implications of Reaching Universal Coverage of Maternity Health Services in Siaya County, Western Kenya
(Public Health Research, 2020)In Kenya, no studies have attempted to model alternative scenarios of the cost-implications of reaching universal coverage (i.e. 95% population coverage) of the existing maternity health services network at the ward ... -
Costs and cost-effectiveness of delivering intermittent preventive treatment through schools in Western Kenya
(BMC, 2008)Awareness of the potential impact of malaria among school-age children has stimulated investigation into malaria interventions that can be delivered through schools. However, little evidence is available on the costs and ... -
Costs and cost-effectiveness of delivering intermittent preventive treatment through schools in western Kenya
(Malaria Journal, 2008-09-30)Background: Awareness of the potential impact of malaria among school-age children has stimulated investigation into malaria interventions that can be delivered through schools. However, little evidence is available on the ... -
Coxiella burnetii in humans, domestic ruminants, and ticks in rural Western Kenya
(The American Society of Tropical Medicine and Hygiene, 2013)We conducted serological surveys for Coxiella burnetii in archived sera from patients that visited a rural clinic in western Kenya from 2007 to 2008 and in cattle, sheep, and goats from the same area in 2009. We also ... -
Decline in childhood iron deficiency after interruption of malaria transmission in highland Kenya1–3
(AJCN, 2014-07-30)Background: Achieving optimal iron status in children in malariaendemic areas may increase the risk of malaria. Malaria itself may contribute to iron deficiency, but the impact of an interruption in malaria transmission ... -
Decrease in numbers of naive and resting B cells in HIV-infected Kenyan adults leads to a proportional increase in total and Plasmodium falciparum–specific atypical memory B cells
(The American Association of Immunologists, Inc., 2017-05-19)Human immunodeficiency virus type 1 (HIV-1) infection is associated with B cell activation and exhaustion, and hypergammaglobulinemia. How these changes influence B cell responses to coinfections such as malaria is poorly ... -
Decreased prevalence of anemia in highland areas of low malaria transmission after a 1-Year interruption of transmission
(Oxford University Press, 2011-11-03)Background. Malaria control campaigns have reduced malaria transmission to very low levels in many areas of Africa. Yet the extent to which malaria interruption or elimination might decrease the prevalence of anemia in ... -
Determinants of HIV Status Disclosure among Adolescents in Bondo Sub-county of Siaya County in Kenya
(Mediterranean Journal of Basic and Applied Sciences (MJBAS), 2021-08-26)With the widespread use of highly active antiretroviral therapy, the epidemic of HIV has evolved into a chronic disease. HIV is extremely stigmatizing, resulting in highly emotionally charged responses to disclosure. World ...