Browsing School of Health Sciences by Author "Gondi, Stacey M. O."
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Increased complement deposition on red blood cells in children with sickle cell trait
Otieno, Walter; Estambale, Benson B.; Odera, Michael M.; Odhiambo, Collins O.; Joash R. Aluoch, Joash R.; Guyah, Bernard; Gondi, Stacey M. O.; Stoute, José A. (BJMMR, 2015)Aims: Immune-mediated mechanism, such as deposition of complement (C3b) on erythrocytes leading to enhanced receptor-mediated uptake by macrophages has been proposed to contribute partly to the destruction of non-infected ... -
Sickle cell trait (HbAS) is associated with increased expression of erythrocyte complement regulatory proteins CR1 and CD55 levels in children
Otieno, Walter; Estambale, Benson B.; Odera, Michael M.; Gondi, Stacey M. O.; Aluoch, Joash R.; Stoute, José A. (International Journal of TROPICAL DISEASE & Health, 2013)Aims: Erythrocyte complement regulatory proteins, complement receptor 1 (CR1) and decay accelerating factor (CD55) protect red blood cells (RBCs) from complement mediated damage by controlling complement activation cascade ...