Browsing School of Health Sciences by Author "Willis, Alecia S."
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An ethnic-specific polymorphism in the catalytic subunit of glutamate-cysteine ligase impairs the production of glutathione intermediates in vitro
Truc M.Le, Truc M.; Willis, Alecia S.; Barr, Frederick E.; Cunningham, Gary R.; Canter, Jeffrey A.; Owens, Sarah E.; Apple, Rachel K.; Ayodo, George; Reich, David; Summar, Marshall L. (ScienceDirect, 2010-09)Glutathione plays a crucial role in free radical scavenging, oxidative injury, and cellular homeostasis. Previously, we identified a non-synonymous polymorphism (P462S) in the gene encoding the catalytic subunit of ...