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Evaluation of three rapid diagnostic test kits in the diagnosis of plasmodium species infections among primary school children in Baringo County, Kenya
(scientific research, 2017)
Background: Due to the difficulty in implementing microscopy-based definitive diagnosis of malaria especially in resource-poor areas, rapid diagnostic test (RDT) kits as alternatives have been developed by different ...
Standardization and validation of a cytometric bead assay to assess antibodies to multiple Plasmodium falciparum recombinant antigens
(BioMed Central Ltd, 2012-12-21)
Background
Multiplex cytometric bead assay (CBA) have a number of advantages over ELISA for antibody testing, but little information is available on standardization and validation of antibody CBA to multiple Plasmodium ...
Decreased prevalence of anemia in highland areas of low malaria transmission after a 1-Year interruption of transmission
(Oxford University Press, 2011-11-03)
Background. Malaria control campaigns have reduced malaria transmission to very low levels in many areas of Africa. Yet the extent to which malaria interruption or elimination might decrease the prevalence of anemia in ...
An ethnic-specific polymorphism in the catalytic subunit of glutamate-cysteine ligase impairs the production of glutathione intermediates in vitro
(ScienceDirect, 2010-09)
Glutathione plays a crucial role in free radical scavenging, oxidative injury, and cellular homeostasis. Previously, we identified a non-synonymous polymorphism (P462S) in the gene encoding the catalytic subunit of ...
The Plasmodium falciparum antigen MB2 induces interferon-γ and interleukin-10 responses in adults in malaria endemic areas of Western Kenya
(PMC, 2013)
Background:
MB2 is a novel Plasmodium falciparum antigen of unknown function expressed in pre-erythrocytic and blood stages of infection in the human host. Interferon-gamma (IFN-γ) and interleukin (IL)-10 responses to ...
Perennial transmission of malaria in the low altitude areas of Baringo County, Kenya
(BMC, 2017)
Background
Malaria causes the greatest public health burden in sub-Saharan Africa where high mortality occurs mainly in children under 5 years of age. Traditionally, malaria has been reported mainly in the lowlands endemic ...
Malaria hotspot areas in a highland Kenya site are consistent in epidemic and non-epidemic years and are associated with ecological factors
(BMC, 2006)
Background
Malaria epidemics in highland areas of East Africa have caused considerable morbidity and mortality in the past two decades. Knowledge of "hotspot" areas of high malaria incidence would allow for focused ...
Determinants of the Uptake of Intermittent Preventive Treatment of Malaria in Pregnancy with Sulphadoxine Pyrimethamine in Sabatia Sub County, Western Kenya
(BMC, 2021)
Annually, 125.2 million pregnant women worldwide risk contracting malaria, including 30.3 million and 1.5 million in Sub-Saharan Africa and Kenya respectively. At least three doses of sulphadoxine pyrimethamine for ...
Determinants of Malaria Prevalence among Children below Five Years in North West Kisumu Ward, Kisumu County, Kenya: A Cross-Sectional Study
(Middle East Journal of Applied Science & Technology, 2021-12-09)
Globally, malaria remains a major public health problem. In 2019 an estimated 229 million cases of malaria were reported, WHO African region accounted for 94% of total cases. In Kenya, malaria is a leading cause of morbidity ...
Spatiotemporal Distribution of Rift Valley Fever and Malaria Vectors in Baringo County, Kenya: Implications on Vector Control
(International Journal of Mosquito Research, 2021-12-17)
Rift Valley Fever and malaria are zoonotic and human diseases respectively that pose major production and health challenges to pastoralists. This study aimed to determine the spatiotemporal distribution of mosquito vectors ...