Over the past few decades, there has been a great leap in the development of Information and Communication Technology (ICT); both in hardware and software capabilities. This has provided a sound platform for their application in relation to healthcare provision in diverse forms. The application of ICT in healthcare, referred to as e-health, is an all-encompassing terminology with health and technology as driving focus. E-health is an idea whose time has come as can be evidenced by the World Health Organization (WHO), urging all its member states to embrace its adoption. Globally, e-health has been significantly embraced by a good number of developed nations with well documented benefits; yet there has been very little in terms of adoption in the developing nations especially in the Sub-Sahara African continent. This paper reviewed e-health adoption globally and in Kenya with the objective of determining barriers and facilitators to its adoption, eliciting interventions to address adoption and to assess evidence available to support potential for improving or promoting e-health. The literature synthesis included as many dimensions as possible that related to barriers and facilitators in both clinical and public health care. This was necessary to identify the scope of the adoption and research experiences; it also permitted broad categorization of relevant issues deliberated on by health/ICT experts. Broadly these were considered in terms of the context, processes involved and the event outcomes