Pathogenicity of Trichomonas hominis in Kenya

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dc.contributor.author Estambale, Benson B.
dc.contributor.author Chunge, CN.
dc.contributor.author Pamba, HO
dc.contributor.author Munanga, P.
dc.contributor.author Kangethe, S.
dc.date.accessioned 2018-06-12T08:11:18Z
dc.date.available 2018-06-12T08:11:18Z
dc.date.issued 1988-08
dc.identifier.issn https://profiles.uonbi.ac.ke/bestambale/publications/pathogenicity-trichomonas-hominis-kenya-east-afr-med-j-1988-aug658532-4
dc.identifier.uri http://ir.jooust.ac.ke:8080/xmlui/handle/123456789/1267
dc.description.abstract An in vitro study of the antinematodal action of two groups of compounds which act on the receptor complex of the inhibitory neurotransmitter, Gamma-aminobutyric acid (GABA) in mammalian systems is described. The compounds, Ivermectin and two benzodiazepines, Diazepam and a water soluble Midazolam were tested singly or in combination against two microfilarial parasites Onchocerca lienalis (closely related to Onchocerca volvulus) and Brugia pahangi. The combination of ivermectin and diazepam at a concentration of 0.1 microgram/ml and 33 micrograms/ml respectively achieved the same effect on microfilarial motility as when ivermectin was given at 1 microgram/ml alone or diazepam at 66 micrograms/ml alone. Similarly when the combination of ivermectin at 0.1 microgram/ml and midazolam at 10 micrograms/ml was used it achieved the same effect as ivermectin at 1 microgram/ml alone or midazolam at 33 micrograms/ml alone. This showed that both benzodiazepines had a synergistic effect on the activity of ivermectin. The microfilariae of B. pahangi were insensitive to both groups of compounds at all concentrations used. en_US
dc.language.iso en en_US
dc.title Pathogenicity of Trichomonas hominis in Kenya en_US
dc.type Article en_US


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