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An ethnic-specific polymorphism in the catalytic subunit of glutamate-cysteine ligase impairs the production of glutathione intermediates in vitro
(ScienceDirect, 2010-09)
Glutathione plays a crucial role in free radical scavenging, oxidative injury, and cellular homeostasis. Previously, we identified a non-synonymous polymorphism (P462S) in the gene encoding the catalytic subunit of ...
Effect of climatic variability on malaria trends in Baringo County, Kenya
(spring open.com, 2017)
Background
Malaria transmission in arid and semi-arid regions of Kenya such as Baringo County, is seasonal and often influenced by climatic factors. Unravelling the relationship between climate variables and malaria ...
Decrease in numbers of naive and resting B cells in HIV-infected Kenyan adults leads to a proportional increase in total and Plasmodium falciparum–specific atypical memory B cells
(The American Association of Immunologists, Inc., 2017-05-19)
Human immunodeficiency virus type 1 (HIV-1) infection is associated with B cell activation and exhaustion, and hypergammaglobulinemia. How these changes influence B cell responses to coinfections such as malaria is poorly ...
CD23-Bound IgE augments and dominates recall responses through human Naive B cells
(American association of immunology, 2010)
Human peripheral blood BCRμ+ B cells express high levels of CD23 and circulate preloaded with IgE. The Ag specificity of CD23-bound IgE presumably differs from the BCR and likely reflects the Ag-specific mix of free serum ...
The Plasmodium falciparum antigen MB2 induces interferon-γ and interleukin-10 responses in adults in malaria endemic areas of Western Kenya
(PMC, 2013)
Background:
MB2 is a novel Plasmodium falciparum antigen of unknown function expressed in pre-erythrocytic and blood stages of infection in the human host. Interferon-gamma (IFN-γ) and interleukin (IL)-10 responses to ...
Impact of land use on the distribution and diversity of entomopathogenic nematodes in Embu and Taita Districts, Kenya
(Tropical and Subtropical Agroecosystems, 2010)
Natural entomopathogenic nematodes(EPNs) are considered as potential biological control agents against soil-borne insect pests. This study was conducted to determine the impact of land use on the distribution occurrence ...
Participation of fishing communities in neglected tropical disease/HIV co-infection Cohort Studies in Western Kenya
(2014)
Background: Fishing communities on the shores of Lake Victoria are at high risk of schistosome infections, and at the same time, also considered at high risk of HIV infection due to factors associated with lifestyle or ...
Perennial transmission of malaria in the low altitude areas of Baringo County, Kenya
(BMC, 2017)
Background
Malaria causes the greatest public health burden in sub-Saharan Africa where high mortality occurs mainly in children under 5 years of age. Traditionally, malaria has been reported mainly in the lowlands endemic ...
High prevalence of Rickettsia africae variants in Amblyomma variegatum ticks from domestic mammals in rural Western Kenya: Implications for human health
(Mary Ann Liebert, Inc, 2015-10)
Tick-borne spotted fever group (SFG) rickettsioses are emerging human diseases caused by obligate intracellular Gram-negative bacteria of the genus Rickettsia. Despite being important causes of systemic febrile illnesses ...
Spatial distribution and habitat characterization of schistosomiasis host snails in lake and land habitats of western Kenya
(John Wiley & Sons, Inc, 2013)
Intermediate host snails of schistosomiasis were surveyed in this study to determine their abundance and distribution in the lake and land aquatic habitats of Lake Victoria basin of Kenya. Several sites were sampled at ...